Neuroscience: Understanding antidepressants
A glimpse of the mechanism involved in antidepressant block of neurotransmitter transporters in the brain is revealed in a paper.Eric Gouaux and colleagues wanted to understand the previously elusive action of tricyclic antidepressant (TCA), to aid the design of new inhibitors.
In humans, inhibiting sodium-coupled transporters has an important role in the treatment of a broad range of neurological diseases and conditions. Gouaux and his team provide mechanistic insights into how such transport proteins are blocked by solving the structure of a prokayotic homologue, in complex with various TCAs, at high resolution. They identify an extracellular-facing cavity in the protein as the site of TCA action and thus as a site with therapeutic potential.
Contact:
Eric Gouaux (Oregon Health and Science University/HHMI,Portland, OR, USA)
Tel: +1 503 494 5535; E-mail: gouauxe@ohsu.edu
Thursday, August 09, 2007
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